Mahomet-Seymour was in the Sangamon Valley Conference from before 1969 to the 1975/76 season.
Mahomet-Seymour did not race in a Conference meet until the 1976 season.
  Mahomet-Seymour was in the Okaw Valley Conference from the 1976/77 season to the 1984/85 season.
Mahomet-Seymour was not in a conference during the 1985/86 season.
Mahomet-Seymour was in the Cornbelt Conference from the 1986/87 season to the 2016/17 season.
Mahomet-Seymour has been in the Apollo Conference from the 2017/18 season to the present.